Popular opiod painkiller associated with increased risk of hypoglycemia

Although the risk is small, it is likely underreported.

Tramadol hydrochloride is a weak opioid whose use has increased steadily worldwide. However, concerns have been raised about the drug and an increased risk for hypoglycemia.

Because of increasing use of the pain-reliever by patients, Jean-Pascal Fournier, M.D., Ph.D., of the Jewish General Hospital, Montreal, Canada, and co-authors examined whether tramadol, compared with codeine, was associated with an increased risk of hypoglycemia severe enough to send patients to the hospital.